A Disintegrin And Metalloproteinase



A Disintegrin And Metalloproteinase (ADAM) are peptidases which cleave off extracellular portions of transmembrane proteins. ADAM inhibitors are used in anti-cancer therapy. ADAM family members are numbered. ADAM10 cleaves ephrin. ADAM17 processes the tumor necrosis factor-α. ADAM33 is implicated in asthma. ADAMTS is ADAM with thrombospondin motifs. ADAMTS1 has anti-angionenic activity. ADAMTS4 and ADAMTS5 are involved in the degradation of aggrecan. ADAMTS13 cleaves von Willebrand factor involved in blood clotting. The images at the left and at the right correspond to one representative ADAM, i.e. the crystal structure of bovine A Disintegrin And Metalloproteinase 10 (2ao7).

3D Structures of A Disintegrin And Metalloproteinase
Update June 2011

ADAM5
3hy7, 3hyg – hADAM5 catalytic domain (mutant) - human

ADAM10
2ao7 – ADAM10 - bovine

ADAM17
1zxc, 2a8h, 2ddf – hADAM17 catalytic domain + inhibitor

2fv5, 2fv9, 2i47, 3b92, 3cki, 3e8r, 3edz, 3ewj, 3g42, 3l0t, 3l0v, 3le9, 3lea, 3lgp - hADAM17 catalytic domain (mutant)+ inhibitor

ADAM33
1r54, 1r55 – hADAM33 catalytic domain

ADAMTS1
2jih, 3q2g, 3q2h - hADAMTS1 catalytic domain + inhibitor

2v4b - hADAMTS1 catalytic domain

ADAMTS4
3b2z - hADAMTS4 residues 213-520

2rjp - hADAMTS4 residues 213-520 (mutant) + inhibitor

ADAMTS5
2rjq - hADAMTS5 residues 262-628 + inhibitor

3b8z, 3hy7, 3hyg, 3ljt - hADAMTS5 catalytic domain (mutant) + inhibitor

ADAMTS13
3ghm, 3ghn - hADAMTS13 exosite-containing fragment (mutant)